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No deuterium incorporation at the α-carbon position of the thioester group in the product clearly indicates that, similar to the real glyoxalase I, the reaction proceeded with deprotonation of the α-proton of hemithioacetal with fluoride base to form the enediol intermediate and subsequent enantioselective protonation

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While exosomes have the ability to merge with the outer membrane of recipient cells and discharge their contents directly into the cytoplasm, it is more frequently observed that exosomes are taken up by recipient cells through endocytosis (Gerasymchuk et al., 2020)