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Consequently, the gut microbiota has gained recognition as a key regulator of appetite and an important determinant in the pathogenesis of obesity (417)

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Endolysosomal zinc dysregulation Defects in the endosome–autophagosome–lysosome pathway, the major machinery for degrading protein aggregates and damaged organelles, are central drivers of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and ALS 166