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Thus, downregulation of NCOA4 inhibits ferritin degradation and reduces free iron level (44)

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subtilis rib operon consists of five genes, ribDG, ribE, ribAB, ribH, ribT , forming one transcription unit (mRNA), and contains the regulatory region ribO , untranslated leader region, that is located with the major promoter P1 (transcription start) upstream of the first structural gene in the operon (Figure 2) ( RibO together with P1, includes the so-called RFN element (FMN riboswitch/ ribDG FMN riboswitch), which is involved in FMN biosynthesis