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changes included Marchi granules and regressive glial cell changes, with demyelinization seen as the 12-week study progressed (Yoshida, 1962)

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Additionally, alanine mutations of E124 3.33 and R283 6.55 also lead to the significantly diminished basal activity of the ghrelin receptor, indicating a potential role of the salt bridge formed by these residues in modulating the receptor’s basal activity (Supplementary Fig