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Activation of autophagy increases levels of stemness, EMT, and resistance to CPT-11 ( Fibroblasts were found to produce exosomal Wnts that reprogram CRC cells into cancer stem cells, conferring resistance to oxaliplatin and 5-FU ( 3 Mechanisms of targeted therapy resistance in CRC 3.1 Changes in drug targets of EGFR and EGFR ligands CRC has been shown to resist cetuximab through mutations on the EGFR extracellular domain, including S492R, R198, R200, R451C, and K467T ( 3.2 Dysregulated activation of alternative receptors: IGF-1R, IGF-2R, HER2, and HER3 Insulin-like growth factor 1 receptor (IGF-1R), IGF-2R, human epidermal growth factor receptor 2 (HER2), HER3, and the hepatocyte growth factor/mesenchymal-epithelial transition factor (HGF/MET) pathway are involved in the activation of the PI3K/Akt and RAS/RAF/MEK/ERK pathways
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[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Noma T, Lemaire A, Naga Prasad SV, Barki-Harrington L, Tilley DG, Chen J, Le Corvoisier P, Violin JD, Wei H, Lefkowitz RJ, Rockman HA
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