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Butyrate, a SCFA derived from probiotic metabolism, downregulates the transcription factor RORγt in Th17 cells, curtailing IL-17A secretion a key driver of lupus nephritis considerably lowering pro-inflammatory cytokines like TNF-α and IL-6 (146) ( Table 2 )

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The dashes (--) indicate doses that would exceed a standard 100-unit insulin syringe capacity at that concentration