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A study that initiated restricting BCAAs by two-thirds at age 16 months while keeping dietary protein levels constant at 18% improved aspects of health but did not increase longevity in either sex of C57BL/6 mice from 23 months of age (Richardson et al., 2021)

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Because of the ubiquitous nature and broad availability of the drug, this has resulted in APAP hepatotoxicity being the most frequent cause of acute liver failure (ALF) in the US2 and other Western countries3