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In recent years, researchers have isolated seven abolane-type sesquiterpenoids (PBSs) from the deep sea fungus Aspergillus floridus YPH1 (Li et al., 2023b), with compound 7 showing a selective inhibitory effect on Erastin/RSL3-induced ferroptosis similar to Fer-1

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Excessive reactive oxygen species accumulation and antioxidant enzyme inhibition (particularly superoxide dismutase) can activate crucial signaling cascades including NF-κB and MAPK, subsequently promoting pro-inflammatory mediator synthesis and release (Tarek et al., 2023