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Collectively, our findings uncover a previously unrecognized SMG1/DNA-PK–NRF2 axis that senses mild oxidative stress to maintain redox homeostasis and promote cell survival, providing new mechanistic insight into adaptive antioxidant signaling in cancer

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Body-weight-based dosing guide (used when greater precision is needed): Low (maintenance/prevention): 2–3 mcg/kg/day Standard (injury/healing): 4–5 mcg/kg/day High (acute/severe): 6–7 mcg/kg/day For a 70 kg patient: standard dose = 280–350 mcg per injection