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Abbreviations ABVN Auricular branch of the vagus nerve AIS Acute ischemic stroke BBB Blood–brain barrier BDNF Brain-derived neurotrophic factor CSD Cortical spreading depolarization FDA Food and Drug Administration GDF11 Growth differentiation factor 11 ICH Intracerebral hemorrhage LC L ocus coeruleus LC3 Light chain 3 L-PGDS Lipocalin-type prostaglandin D synthase IL I nterleukin MCAo Middle cerebral artery occlusion mRS Modified Rankin scale NIHSS N ational Institute of Health stroke scale NTS Nucleus tractus solitarius nVNS Non-invasive vagus nerve stimulation PPAR-γ Peroxisome proliferator-activated receptor-gamma rIL-17A Recombinant IL-17A TBI Traumatic brain injury taVNS Transcutaneous auricular vagus nerve stimulation tcVNS Transcutaneous cervical vagus nerve stimulation VEGF V ascular endothelial growth factor VNS Vagus nerve stimulation α7nAChR α7 Nicotinic acetylcholine receptor subunit Footnotes Conflict of Interest Sasan Andalib, Cenk Ayata, Ethem Murat Arsava, Mehmet Akif Topcuoglu, Eder Leonardo Cáceres, Vinay Parikh, Masoom J Desai, Sara Girolami, and Mario Di Napoli each declare no potential conflicts of interest

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