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Platinum-based drugs, such as cisplatin and carboplatin, are known to maintain very high ROS levels, inducing DNA damage and cancer cell death by promoting oxidative stress, especially the overproduction of mitochondrial ROS and the reduction of intracellular antioxidants such as glutathione in some human malignancies (Mikuła-Pietrasik et al., 2019)

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& Tyka, R