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However, we did not observe significant differences in circulating IGF-1 levels with mAb treatment in older mice, though levels tended to be higher in mAb-treated females, but glucose homeostasis was not adversely affected in either sex, suggesting minimal disruption of the somatotropic axis in this older cohort of mice

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Microinjections of 3 nmol galanin into the dorsal periaqueductal grey matter impaired learned anxiety in rats without changing unconditioned fear, suggesting an inhibition of acquisition of anxiety-like responses [190]