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Introduction Arsenic trioxide (As 2 O 3 ) is the main component of traditional Chinese medicine “Pishuang”, which has an application history of over 2000 years

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Estrogen withdrawal generates a drastic change in the gut microbiome composition, in turn leading to the dysregulation of microbial synthesis and secretion of important neurotransmitters, such as 5-HT and gamma-aminobutyric acid (GABA) (298, 299)