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In addition, stereotactic biopsy of BM is not part of current practice except in cases of diagnostic uncertainty, such as in the setting of autoimmune disease or immunosuppression, particularly when other metastatic disease is absent [37]

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For Live dead assays, GBM cells were plated at a density of 250,000 cells/well and treated with 20 μM CKi under 1% O 2 hypoxia for 24 h