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Management of metabolic and hemodynamic disturbances is critical for preventing and delaying the progression of diabetic nephropathy

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Network and text mining analyses have further shown that a number of transcription factors are shared in the fasting and feeding process between metabolically active organs, including PPARα, HNF4Α, GR, SREBP-1/2, p53, FOXO, early growth response protein 1 (EGR1), AP-1 (c-FOS/c-JUN), Myc proto-oncogene protein (c-MYC), transcription factor Sp1 (SP1), YY1, and protein C-ets-1 (ETS1) (Hakvoort et al