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The American Society of Clinical Oncology (ASCO) 2020 guidelines recommend that all patients anticipated to receive systemic anticancer therapy should undergo HBV screening using three markers—HBsAg, anti-HBc total immunoglobulin, and anti-HBs—prior to or at the initiation of therapy, with prophylactic antiviral treatment continued throughout anticancer therapy and for at least 12 months thereafter ( Supporting the importance of proactive screening and prophylaxis, previous studies have demonstrated that serial monitoring of serum HBV DNA levels effectively prevents HBVr in patients with B-cell non-Hodgkin lymphoma and a history of HBV infection ( For the patient in the present case, following dalpiciclib-induced life-threatening liver failure, permanent discontinuation of dalpiciclib is mandatory

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The functional capacity of these proteins varies depending on pathological conditions