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However, the colonic absorption of caffeine following coffee enema considerably differs from that following administration of a PCDC or a rectal suppository because the coffee enema procedure usually involves administration of a larger volume of warm and diluted coffee solution (about 500 mL) into the rectum and colon through the anus

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A via oral é considerada para indicações gastrointestinais, com absorção limitada pela digestão enzimática