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10.1371/journal.pone.0099532 219 PietrzakA.BanasiukM.SzczepanikM.Borys-IwanickaA.PytrusT.WalkowiakJ.et al (2022)

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However, its rapid clearance also means that each administration provides a discrete, time-limited growth factor pulse rather than sustained stimulation, which some researchers consider advantageous for mimicking physiological signaling patterns