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Distributed under the brand names Geref and Geref Diagnostic, it gained FDA approval in 1997 as a treatment for growth hormone deficiency but was discontinued in 2008 — not out of concern for safety or lack of efficacy, but because of manufacturing difficulties.2 3 Yet it remains available in compounded form with a prescription from a licensed healthcare provider

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Alternatively, a lack of vitamin B 12 or folate coenzymes secondary to vitamin deficiency resulting from malabsorption or inadequate intake can also cause a lack of Hcy remethylation

Glutathione (GSH) is an important antioxidant in plants