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Among the arsenal of antioxidants and detoxifying enzymes existing in mitochondria, mitochondrial glutathione (mGSH) emerges as the main line of defense for the maintenance of the appropriate mitochondrial redox environment to avoid or repair oxidative modifications leading to mitochondrial dysfunction and cell death

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Another study using NR supplementation showed that doses up to 1000 mg per day for 10 weeks were well tolerated in patients affected by mild cognitive impairments (MCI) 246