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TABLE I Solubility, distribution coefficient, Percentage of unionized drug and skin permeability parameters of ibuprofen TABLE II Solubility, distribution coefficient, % of unionized drug and skin permeability parameters of Aceclofenac TABLE III Solubility, distribution coefficient, percentage unionized, and skin permeability parameters of Glipizide TABLE IV Solubility, distribution coefficient, percentage unionized, and skin permeability parameters of olanzapine TABLE V Solubility, distribution coefficient, percentage unionized, and skin permeability parameters of telmisartan TABLE VI Solubility, distribution coefficient, % unionized and Skin permeability parameters of sildenadil citrate The effect of solubility and partition coefficient on skin permeability is a well-documented phenomenon