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Patients will die if adrenal insufficiency is not diagnosed promptly and treated effectively [Oelkers, 1996] and longevity may be reduced as a consequence of stress-induced crises [Arlt and Allolio, 2003]

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When PI3K and its regulatory proteins, p85 and p110, are recruited by IRS, they will further recruit and activate PDK1 (PIP 3 -dependent kinase 1), Akt (PKB), mTORC2, S6 kinases and PKC