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Taken together, these findings indicate that liver regeneration was delayed in both WT and HuR Hep-/- male mice at 24 hours following a 200 mg/kg APAP overdose, and that Cyclin D1 expression and thus early cell cycle entry may be further impaired in HuR Hep-/- livers relative to WT

though results will vary based on individual commitment to exercise and diet.