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These investigators observed no association with GSTM1 null genotype overall (age-adjusted OR = 1.0, 95% CI 0.7–1.5)

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a high-cardiovascular-risk kidney cohort showed a slower decline in kidney function and about a third less protein leak, which travels to a similar-risk body, not a healthy one.⁶ ¹⁴ Lean and metabolically healthy: a safety read, not an efficacy target No long trial has tested tirzepatide in lean, metabolically healthy people