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showed that ferroptosis inhibition improves depressive behavior in a chronic unpredictable mild stress mouse model [95, 96] Stress induced anxiety after 14 day chronic restrain stress showed ferroptosis, with higher oxidative stress and lipid peroxidation markers [97]

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However, its cosmetic status also means it is not held to the same efficacy-proof standard as an approved drug, and higher-concentration or injectable forms marketed for research use are not approved for human therapeutic use and fall into a legal grey area that varies by jurisdiction