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Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19)

Global metabolomics further revealed that NRF2 activation induced NAD + -consuming detoxification enzymes aldehyde dehydrogenases to cause hepatic NADH-reductive stress, whereby a redox imbalance of high NADH/NAD + ratio reprogramed hepatic metabolism to prevent lipid accumulation in Cul3-deficient livers

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Pharmacologyonline 1 , 82–89 (2021)