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Pharmacological activation of SIRT3 by small molecules, namely 7-hydroxy-3-(4′-methoxyphenyl) coumarin (C12), also represents a promising approach to prevent mitochondrial ROS via deacetylation and activation of MnSOD (121)

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Therefore, further investigation is needed to better understand how sex affect CKD incidence, prevalence, and progression, in addition to potential sex-specific disease markers to determine whether sex hormones are related to the onset or progression of renal disease [24]