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The activation of mitogen-activated protein kinase (MAPK) cascades comprising three tiers of kinases—the MAPK kinase kinase (MAPKKK/MEKK), the MAPK kinase (MAPKK/MKK) and the MAPK (MPK)—upon MAMP perception represents a conserved innate immune signalling event in metazoans and plants 3

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Mechanistic studies indicate that in this subset of cells, Gstt1 maintains metastases by binding to and modifying intracellular fibronectin, regulating Fibronectin secretion from cancer cells and deposition into the metastatic microenvironment