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Therefore, inhibiting NAMPT (for example, using KPT-9274) can selectively exhaust NAD⁺ pools in these niche-resident macrophages, thereby reversing their immunosuppressive phenotype and sensitizing the TME to immune checkpoint blockade

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Unfortunately, most current therapies offer only temporary relief, often come with undesirable side effects, may interfere with the ability to conceive, and carry a risk of symptom recurrence after discontinuation