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Oxidative stress plays a key role in this process, contributing to RPE degradation and drusen accumulation [42]

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Table 14: Characterisation of thermal unfolding and aggregation behavior with nanoDSF as a function of formulation NaCI [mM] T m 1 [°C] T agg [°C] ~ 0 52.9 ± 0.0 52.5 ± 0.1 100 51.7 ± 0.0 50.6 ±0.0 200 51.0 ± 0.0 49.3 ±0.1 [377] Example 8: Two BCMA targeting BiTE® antibody constructs with (BiTE ® F) and without (BiTE ® E) an additional cys-clamp in the domain directed against BCMA and containing a single-chain Fc domain at the C-terminal end were formulated in 10 mM L-glutamic acid, 9% (w/v) sucrose at pH 4.8