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Metformin rescues osteoblast fate in Glucocorticoid-associated osteonecrosis of the femoral head via PERK/CHAC1/GSH-mediated reprogramming of glutathione homeostasis - ScienceDirect

Another promising strategy involves combining antifungal agents with non-traditional pharmacological compounds

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The proportion of patients with Karnofsky Performance Status scores ≤70 increases from 17.1% in those under 70 years to 46.1% in the 80-89 age group