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CDK5 mediates stemness in triple-negative breast cancer (TNBC) by phosphorylating Peroxisome proliferator-activated receptor gamma (PPARγ) at S273 (Table 2), which curbs its E3 ligase activity and releases epithelial splicing regulatory protein 1 (ESRP1)

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The thresholds for Iwp (high), Iwp (low) and Ip (low) were 200, 140, 80 for 4HNE, 200, 125, 75 for Cytochrome c, 200, 125, 75 for ferritin, 200, 115, 70 for ferroportin, 200, 150, 70 for GPX4 and 200, 135, 70 for NCOA4, respectively