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The same research group, in 2001, observed a significant increase in the muscle concentrations of Krebs cycle intermediates, such as citrate, malate, fumarate and succinate, at the beginning of the exercise (bicycle exercise at 70% of the VO 2max ) after acute glutamine supplementation, when in comparison with ornithine α-ketoglutarate or placebo administration

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This protective mechanism is likely linked to the prevention of lipid ROS accumulation in plasma membranes and the reduction of phospholipids containing oxidizable PUFAs, an effect that requires ACSL3 activation