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This was done in the presence of the CI-linked substrates pyruvate (5 mM), malate (2 mM) and in the absence of ADP (2.5 mM) followed by the addition of cytochrome c (10 µM) to test for the integrity of the mitochondrial outer membrane (cytochrome c control efficiency)

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Os GLP-1s passaram por extensos testes humanos e são aprovados, por exemplo, pelo organismo regulador de medicamentos do Reino Unido (a MHRA)