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Therapeutically, modulation of brain-resident immune cells has been explored, particularly by promoting gene expression profiles associated with an M2-like phenotype, primarily in microglia, though similar strategies in BAMs require further investigation ( Moreover, BAMs, especially PVMs, influence not only stroke response but also stroke risk by contributing to neurovascular dysfunction in hypertension, the major risk factor for stroke ( Gut microbiota interactions with brain-resident immune cells Recognising that both the gut microbiota and brain-resident immune cells significantly modulate stroke outcomes, a regulatory pathway integrating the gut-brain axis emerges as a compelling area of investigation

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Category 2 is the designation FDA uses for nominated substances that raise significant safety questions and that the agency does not intend to permit in compounding while review is underway