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Further studies using various mammalian cell lines—including human embryonal carcinoma (P3), human skin keratinocytes (HaCaT), mouse leukemia cells (L1210) and Chinese hamster ovary (CHO)-derived reporter cells (AS52)—confirmed that blue light (400–500 nm, up to 42 kJ/m 2 ) induces multiple types of DNA damage, including strand breaks 171