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According to current clinical practice guidelines for pharmacological management of obesity published in 2015 by The Endocrine Society, if a patient’s weight is not responsive to lifestyle intervention, weight loss pharmacotherapy can be offered for a BMI ≥27kg/m 2 when an obesity-related comorbidity is present, or when the BMI is ≥30kg/m 2 (1)

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The 2.4mg weekly dose produced an average 14.9% body weight reduction at 68 weeks in participants with obesity, a number that at the time seemed extraordinary