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Patients with renal diseases had very low GPX3 activity, including those undergoing renal dialysis

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A small study found that men with GSTT1 null genotypes were at an 11-fold increased risk of Parkinson’s with paraquat exposure.[ref] This ties together with MAO-B — the GST enzymes help combat the oxidative stress from high H2O2 levels due to MAO-B expression

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