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Figure 2 A balanced gut microbiota is characterized by diversity, symbiosis, and robust metabolic activity, with beneficial bacterial genera such as Bifidobacterium, Lactobacillus, and Akkermansia contributing to intestinal homeostasis ( Escherichia coli and Clostridioides difficile can promote inflammation when they proliferate ( One critical mechanism through which gut bacteria influence inflammation involves the production of short-chain fatty acids (SCFAs), such as butyrate, acetate, and propionate ( Conversely, harmful bacterial products such as LPS exacerbate inflammation and metabolic dysfunction