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The present study, for the first time to the best of our knowledge, revealed that hydrogen-rich saline induced modulation of necroptosis and neuroinflammation via the ROS/HO-1 pathway, and also provided a novel insight into evaluating the biological impacts as well as the mechanisms that underly neuroprotection and inhibition of inflammation and necroptosis by hydrogen-rich saline

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This framing complements broader or single-disease reviews (e.g., DiPalma et al., 2024