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Supporting Information Acknowledgments The authors are grateful to Olaf Iván Corro Labra and José Luis de Jesús García Ruíz from the “Comisión Nacional para el Desarrollo de los Pueblos Indígenas” for their support in this work

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So far, the therapeutic benefit of biased signaling of β 3 -AR selective agonists/antagonists in metabolic pathologies is unclear (Michel and Charlton, 2018)