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Synergistic effects and safety should be evaluated in standardized models to concurrently achieve inflammation regulation and tissue regeneration

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Later studies in differentiated N27 cells also demonstrate that chronic low-dose Mn exposure impairs tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine synthesis, through activation of PKCδ and protein phosphatase-2A (PP2A) activity (Zhang et al., 2011)

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