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Gut microbiota orchestrates ACh homeostasis through multifactorial mechanisms: specific strains (e.g., Lactobacillus plantarum Lsi ) secrete ACh-like compounds, directly enhancing intestinal contractions (Fujita et al., 2024)

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The resulting increase in mitochondrial glutaminase expression (GLS1) promoted flux through the tricarboxylic acid cycle (TCA) and more robust glutathione biosynthesis