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For instance, manifestation of radiation toxicity at the cellular level involves simultaneous activation of various pro-survival and cytotoxic pathways in a ROS-dependent (indirect effect of radiation) and independent (direct effect of radiation) manner [37, 40, 100]

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The Kappa concordance between QTF and TST was estimated: moderate in the whole sample, poor in patients treated with GC at screening, and substantial when the patients treated with GC at screening were excluded