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As expected, this data was very similar to that collected for the U597C SmTGR variant with each delineated event occurring on similar time frames ( k obs values for this data set include: k 1 of 560–1,30 s −1 , k 2 of 125–159 s −1 , a k 3 of 0.3–3.1 s −1 , and a k 4 of 0.005–0.02 s −1

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Heat shock leads to a disruption of mitochondrial homeostasis such as an increase in mitochondrial ROS production and subsequently oxidative damage of mitochondria