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224 It mainly comprises the cascade kinase cascade transcription molecule mammalian STE20-like kinase 1/2 (MST1/2), WW domain of Sav family containing protein 1 (SAV1), and MOB kinase activator 1 (MOB1), with large tumor suppressor 1/2 (LATS1/2) upstream and Yes-associated protein (YAP)/effector molecules with PDZ- binding motif (TAZ) downstream

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Additionally, ER stress can induce AMPK activation via increased cytosolic Ca 2+ levels, providing an alternative route for autophagy initiation (Høyer-Hansen et al., 2007)