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Once NAC promotes production of glutathione, glutathione is incorporated into crucial antioxidant enzymes (e.g., glutathione peroxidase and glutathione reductase) and detoxification enzymes (glutathione S-transferases)

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The PLD2-mediated low-level ROS generation by receptor-internalizing or endogenous opioids might be one reason for a lower neurotoxicity compared with noninternalizing opioids under physiologic conditions and this might have implications for analgesic therapy