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The secretion of GH in both fish and mammals follows a pulsatile, circadian pattern, with relatively higher release during the dark phase ( Main Hormonal Regulators of Somatotrophs—GHRH and Somatostatin Two brain (hypothalamus)–derived modulating factors, the stimulator GHRH and the inhibitor somatostatin ( Figure 1 ) (26, 71, 72)

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These protective effects suggest that bromelain holds potential as a therapeutic agent for managing oxidative and inflammatory damages associated with IR conditions, warranting further clinical investigation

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