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72, 5126–5134, doi: 10.1128/IAI.72.9.5126-5134.2004 (2004)

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The normalized datasets of ESI − and ESI + modes were combined and input into SIMCA 13.0 software (MKS Umetrics, Malmö, Sweden) to conduct various multivariate data analyses, namely, principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and orthogonal partial least squares discriminant analysis (OPLS-DA)