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The impact of mitochondrial impairments on sperm function and male fertility: a systematic review | Reproductive Biology and Endocrinology | Springer Nature Link

Synaptic terminal glutamate-induced Ca 2+ transients activate neuronal nitric oxide synthase (nNOS)-mediated NO · generation, and additionally, Ca 2+ overloaded in the mitochondria induces O 2 − /H 2 O 2 generation which can lead to ONOO · production and excitotoxicity [18,19,20]

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↑ "Gastric alcohol dehydrogenase activity in man: influence of gender, age, alcohol consumption and smoking in a caucasian population"